BA Physics, UC Berkeley, 2013 BS Business Administration, UC Berkeley 2013 C.V.
Lanthanide upconversion offers many biologically compatible features not found in current voltage and pressure sensors.
The long-lived f-f transitions of lanthanide ions allow for absorption of near infrared (NIR) photons and emission in the visible.
This is advantageous because biological tissues and organs do not absorb and luminesce under NIR.
Additionally, upconverting nanoparticles exhibit sharp anti-Stokes emissions, do not photobleach or blink,
and are less toxic and invasive than options like quantum dots.
My goal is to create voltage and pressure sensitive upconverting nanoparticles
whose emission change as a result of an external bias or force.
Specifically, I am looking at piezoelectric and d-metal/lanthanide-doped nanomaterials.
This promises active or live imaging of bioelectrical signals like neuron firing, heartbeats, and other muscle contractions.
Due to the interdisciplinary nature of this research, we collaborate with groups from Stanford Medical School and NeuroFab.
A. Lay, D. Wang, M. Wisser, R. Mehlenbacher, Y. Lin, M. Goodman, W. Mao, and J. Dionne. “Upconverting nanoparticles as optical sensors of nano- to micro-Newton forces,” submitted (2017).
Y. Zhao, A. Saleh, M.-A. van de Haar, J. Briggs, A. Lay, O. Reyes-Becerra, J. Dionne. "Visualizing enantio-selectivity with chiral optical force microscopy," in review (2017).